Acanthosis nigricans
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Čest je kod pretilih ljudi.
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ReferencesAcanthosis nigricans je kožna manifestacija temeljnog stanja. Često se pojavljuje u kožnim naborima poput vrata, pazuha i prepona, izgledaju kao baršunaste tamne mrlje s nejasnim rubovima. Ovo stanje obično je povezano s dijabetesom i inzulinskom rezistencijom, ali u rijetkim slučajevima može ukazivati na rak unutar tijela. Također se može pojaviti zbog problema s hormonima ili uzimanja određenih lijekova, kao što su steroidi i kontracepcijske pilule.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) je uobičajeno stanje kože povezano s raznim zdravstvenim problemima, poput inzulinske rezistencije, dijabetesa, pretilosti, određenih vrsta raka, hormonalnih poremećaja i reakcija na lijekove. Liječenje AN‑a usmjereno je na rješavanje temeljnih zdravstvenih problema. U početku liječnici provjeravaju znakove sindroma inzulinske rezistencije, koji uključuje pretilost, povišen kolesterol, visok krvni tlak i dijabetes tipa 2. Liječnici često propisuju topical retinoids kao prvi izbor liječenja, koji mogu pomoći kod zadebljanja kože, iako možda neće u potpunosti ukloniti tamnjenje. Druge opcije liječenja, poput salicylic acid, podophyllin, urea i calcipotriol, također zahtijevaju čestu primjenu.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Uzroci
Obično se javlja kod osoba mlađih od 40 godina, može biti genetski naslijeđena i povezana s pretilošću ili endokrinopatijama, poput hipotireoze, akromegalije, bolesti policističnih jajnika, inzulinskog otpornog dijabetesa ili Cushingove bolesti.
○ Liječenje – OTC lijekovi
#40% urea cream